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    dcyphr-d by Vincent Lam on 2020-06-18
    AbstractThis is a phase three clinical trial in which the authors of this paper are testing the outcomes of giving the antibody, ipilimumab, to patients who had stage III melanoma tumors successfully removed. The dose of ipilimumab in this trial is 10 mg per kg of body weight. The patients examined in this study were randomly assigned to receive either ipilimumab or placebo. The survival, recurrence rates, and distant metastasis rates of these two groups were measured about 5.3 years after the s...
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    dcyphr-d by Vincent Lam on 2020-06-18
    IntroductionItaly was the first European country to be impacted by COVID-19. At the time this article was published, Italy had about 130,000 COVID-19 cases, and the city of Bergamo had the most infections and deaths. People with COVID-19 often suffer from severe respiratory ailments. Emerging evidence seems to suggest that the respiratory tract isn’t the only part of the body at risk of damage from COVID-19. Tissue damage in COVID-19 patients are often caused by the immune system rather than the...
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    dcyphr-d by Vincent Lam on 2020-06-18
    Significance / AbstractInvasive species are species that are not native to a certain area. When they enter a new area, they can harm the area's environment, plants, and animals. This article is concerned with invasive species' potential to harm global agriculture. The authors of the article aim to determine which countries are hit the hardest by invasive species and which produce the most invasive species threat.IntroductionInvasive species cause crop loss, reducing food supplies and agricultura...
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    dcyphr-d by Vincent Lam on 2020-06-18
    SummaryThe retrovirus HaMSV was used to introduce activated ras genes to mice. After the tumor promoter TPA was added, the same mice developed benign tumors. Some benign tumors eventually became malignant. Cells initiated by HaMSV can remain in the body for at least four months. This study shows that activating ras genes in mice has the same effect as giving them chemical carcinogens. This suggests that ras and other oncogenes have an important role in tumor development.IntroductionCancer develo...
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    dcyphr-d by Vincent Lam on 2020-06-18
    Abstract   COVID-19 has caused great damage to public health and healthcare systems, so slowing its spread is a priority. The authors of this paper studied different types of COVID-19 transmission and how much they account for the virus’s overall spread. They then used this information to figure out what is needed for isolation and contact tracing to be effective in curbing spread. From the insight they gained, they believe that contact tracing is best implemented using an app. They also cover e...
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    dcyphr-d by Vincent Lam on 2020-06-18
    Abstract   Chagas disease affects thousands in America, and diagnosis of chronic Chagas diseases requires two different tests. Four tests that are currently available include the Hemagen, Ortho, Wiener, and InBios tests. In this paper, the authors test the accuracy of these tests. From the results they obtained, they also suggest which sorts of tests to use as the two required diagnostic tests.    Introduction   Chagas disease is a tropical disease common to North, Central, and South America. It...
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    dcyphr-d by Vincent Lam on 2020-06-18
    AbstractIt is important to understand the future of how COVID-19 will spread if we are to control it. The authors of this article examined known info on other viruses in the coronavirus family. They used this info to make models to predict how COVID-19 will spread after this initial pandemic. From these models, they predicted that after the pandemic, recurring outbreaks of COVID-19 will take place during subsequent winters. To avoid having more COVID-19 cases than hospitals can handle, social di...
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    dcyphr-d by David Chen on 2020-06-18
    AbstractThe ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium has systematically documented the variation in whole genomes associated with cancer across 38 tumour types and 2,658 whole cancer genomes. Most cancer genomes will experience 4 to 5 driver mutations in the whole genome. About 5% of cancer genomes do not have any identified driver mutations, which suggests that research towards cancer driver mutations is incomplete. Both common and rare variants of mutations, such as point mut...
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    dcyphr-d by David Chen on 2020-06-18
    AbstractYilong et al. have developed a method to classify the variation of segments of the genome due to rearrangement of different segments. Method is based on sequencing data sourced from the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium, comprising of 2,658 whole genome cancer samples across 38 tumour types. Sixteen signatures of structural variation have been identified. Deletions and translocation of genome segments occur with characteristic lengths and locations. A variety of gen...
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    dcyphr-d by David Chen on 2020-06-18
    AbstractPrevious research has examined mutational signatures in terms of single base substitutions. Further classification of small mutational events can provide a systematic and thorough analysis of the landscape of mutations that exist in cancer genomes. SigProfilerMatrixGenerator is a tool designed to analyze and visualize the mutational patterns found in cancer genomes. The tool produces fourteen matrices, each comprised of distinct classifications for single base substitutions, double base ...